Save the Date: Targeting the Pathway: Evolving Roles of MEK Inhibitors in NF1-Associated PN

Faculty

Darren Hargrave, MB.Chb (Hons), MD, MRCP, FRCPCH
Clinical Professor in Paediatric Neuro-Oncology
University College London Great Ormond Street Institute of Child Health
Honorary Consultant Paediatric Oncologist
Great Ormond Street Hospital for Children
London, UK

Statement of Need

Neurofibromatosis type 1 (NF1) is a common autosomal dominant genetic disorder characterized by tumor predisposition and a wide spectrum of neurologic manifestations. Among its most serious complications are plexiform neurofibromas (PNs), which can cause significant morbidity due to pain, disfigurement, neurologic impairment, and risk of malignant transformation. Despite advances in understanding NF1 biology, care remains complex and often fragmented across specialties, leading to delayed recognition and limited access to evolving therapies. Recent clinical evidence has established MEK inhibitors as targeted therapeutic options for NF1-associated PNs. Incorporating these therapies into practice requires careful patient selection, safety monitoring, and interprofessional coordination to ensure optimal outcomes.

This CE Concepts livestream symposium will address these critical gaps by equipping neuro-oncologists, neurosurgeons, radiation oncologists, medical oncologists, advanced practitioners, and nurses with strategies for early recognition of NF1-associated tumors, effective integration of MEK inhibitors, and development of evidence-based, interprofessional care plans that support individualized, longitudinal management.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

  • Assess neuro-oncologic features of NF1, including tumor types and neurological signs, to support early recognition and guide clinical decision-making
  • Integrate MEK inhibitors in the management of NF1-associated PNs in adult and pediatric patients
  • Develop evidence-based, interprofessional care plans for patients with NF1 that reflect current clinical standards and support individualized, longitudinal management

Financial Support

This program is supported through an independent educational grant from Alexion Pharmaceuticals.

Target Audience

Neuro-oncologists, neurosurgeons, radiation oncologists, medical oncologists, physician associates (PAs), nurse practitioners (NPs), and nurses

Credit Information

Jointly Accredited Provider

In support of improving patient care, Creative Educational Concepts, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physicians (ACCME)

Creative Educational Concepts, LLC, designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Nurses Credentialing Center

This activity is designated for 1.00 contact hours.

Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology.

American Nurses Credentialing Center with ILNA

This activity is designated for 1.00 contact hours.

The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points in the following ILNA subject areas:

OCN® 

  • ​​Care Continuum
  • Oncology Nursing Practice
  • Symptom Management, Palliative Care, Supportive Care
  • Treatment

CBCN® 

  • ​Care Continuum
  • Symptom Management, Palliative Care, Supportive Care
  • Treatment

CPHON® 

  • Care Continuum
  • Pediatric Hematology and Oncology Nursing Practice
  • Symptom Management, Palliative Care, Supportive Care
  • Treatment

AOCNP® 

  • Care Continuum
  • Care of the Pediatric Hematology and Oncology Patient
  • Disease Related Biology
  • Symptom Management, Palliative Care, Supportive Care
  • Treatment

Interprofessional Continuing Education

This activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education Credit for learning and change.

Physician Assistants (AAPA)

Creative Educational Concepts, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.

ABIM MOC

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

European Physicians (EACCME)

Through a mutual recognition agreement between the AMA and the UEMS-EACCME, European physicians completing an e-learning activity from a US-based ACCME-accredited CME provider can use AMA PRA Category 1 Credit™ toward their credit requirements. CE Concepts is based in Radnor, Pennsylvania, USA. Please retain your certificate as proof of completion.

Disclosure Declaration

It is the policy of CE Concepts, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CE Concepts, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

The following individuals have no financial relationships to disclose:

Alaa Bawaneh, MD, PhD (Peer Reviewer)
Jessica Giddens, DNP, APRN, FPMHNP-BC, RN-BC (Peer Reviewer)
Thomas Mitchell, MSW, LSW (Planning Committee)
Nichole Lainhart (Planning Committee)
David Modrak, PhD (Planning Committee)
Alexis Oneca (Planning Committee)
Scott J. Hershman, MD, FACEHP, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (0% pass rate required). This website supports all browsers except Internet Explorer for Mac.

Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CE Concepts, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (0% pass rate required). This website supports all browsers except Internet Explorer for Mac.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac.

Visit the Creative Educational Concepts Privacy Policy page for complete information about our privacy policy and practices.

Questions about this activity?

Call us at 859-260-1717  •  info@ceconcepts.com

MMS-161-112125-87

Call us at 859-260-1717  •  info@ceconcepts.com

Save the Date: Targeting the Pathway: Evolving Roles of MEK Inhibitors in NF1-Associated PN
Activity Date: 11/21/2025 at 10:15 PM EST