New Horizons in Ovarian Cancer: Expert Insights into the Role of Genetic Biomarkers in Precision Therapy
Attendees of these regional meetings will gain an appreciation of the genes involved in the DNA damage response pathways and their role in tumorigenesis, the latest guidelines on genetic testing/counseling for mutations in this pathway, and the clinical implications of testing results (such as the use of PARP inhibitor for treatment). There will also be extensive discussion about the evolving role of the OB/GYN practitioner in genetic testing/counseling and management of ovarian cancer survivors on PARP inhibitor therapy.
Presented by Creative Educational Concepts, Inc.
Supported through an independent educational grant from AstraZeneca and Merk.
This activity is targeted to gynecologists, obstetricians, and other related healthcare professionals attending the 2021 American College of Obstetricians and Gynecologists (ACOG) Clinical District Meetings.
- Review the DNA damage response (DDR) pathway and its role in tumorigenesis of ovarian cancers and outline the various mutations that cause defects in this pathway.
- Review the latest clinical recommendations on genetic testing and counseling in ovarian cancer and discuss the therapeutic implications of identifying mutations in the DDR, as well as other relevant markers of genomic instability (e.g., HRD).
- Discuss current and emerging clinical data regarding the safety and efficacy of PARP inhibitors in ovarian cancer patients.
- Assess the evolving role of OB/GYN practitioners for genetic testing/counseling in patients who are at risk for or have deficiencies in the HRR pathway and discuss multidisciplinary strategies to ensure the appropriate management of patients on PARP inhibitors.
5 min Welcome and Introductions/Pre-test
15 min The DNA Damage Response Pathway: BRCA and Beyond
15 min PARP Inhibitors in Ovarian Cancer Treatment: A Possible Achilles Heel?
20 min Improving Patient Outcomes in Ovarian Cancer: Practical Strategies for the OB/GYN Practice
5 min Conversations with the Experts/Audience Q&A/Post-test
Robert M. Wenham, MD, MS, FACS, FACOG
Chair and Director of Research, Department of Gynecologic Oncology
Senior Member, Chemical Biology and Molecular Medicine Program
Moffitt Cancer Center
Dr. Wenham is the Department Chair and Director of Research in Gynecologic Oncology at the Moffitt Cancer Center in Tampa, Florida. After undergraduate and graduate training in Biochemistry and Molecular Biology, he completed his Medical Doctorate at Southwestern Medical School in Dallas, Texas. He then completed an internship and residency at the Harvard Medical School integrated residency program (The Brigham and Women's Hospital/Massachusetts General Hospital) in Obstetrics and Gynecology in Boston, Massachusetts, and his fellowship in Gynecologic Oncology at Duke University in Durham, North Carolina. He currently is in the Department of Gynecologic Oncology at the Moffitt Cancer Center. His academic career consists of clinical gynecologic oncology; the training of fellows, residents, and medical students; research-related administrative and service roles; and clinical/translational research in oncology. He is a principal investigator (PI) on several consortia, industry, and investigator-initiated trials. He has been the lead Pl for one of the largest prospective cancer tissue and data trials (TCCP) ever conducted, and that trial is setting the foundation for discovery in the epidemiology, detection, and treatment of malignancies. He also serves on national and international advisory boards and steering committees, as well as being an active member of several professional societies.
In accordance with the Food and Drug Administration, the speakers have disclosed that there is the potential for discussions concerning off-label uses of a commercial product/device during this educational activity.
Any person who may contribute to the content of this continuing education activity must disclose relevant relationships (and any known relationships of their spouse/partner) with commercial interests whose products or services are discussed in educational presentations. A commercial interest is defined as any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients. Relevant relationships include receiving from a commercial interest research grants, consultant fees, travel, other benefits, or having a self-managed equity interest in a company.
Disclosure of a relationship is not intended to suggest or condone any bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation.
Vanessa Carranza, PharmD–has no relevant financial relationships to disclose in relation to the content of this activity.
Ursula Matulonis, MD–has disclosed he is a consultant for AstraZeneca, Merck, NextCure, and Novartis. He receives financial or material support from DSMB and Symphogen.
Angeles Alvarez Secord, MD– Disclosures to come.
Robert M. Wenham, MD, MS, FACOG, FACS–has disclosed that he is a consultant for GSK/Tesaro, Merck, Ovation Diagnostics, Regeneron and Seagen. He receives grant/research support from Merck. He is a major stock shareholder in Ovation Diagnostics and is on the speakers bureau for ONC Live and Curio Science.
In support of improving patient care, Creative Educational Concepts is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
CEC designates this live, virtual educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Upon completion of a CE request form, statements of credit for physicians will be issued.
This is an independent CME Satellite Event and is not part of the official ACOG District XII 2021 Annual District Meeting.
This webinar will be presented by CEC Oncology and is supported through independent educational grants from AstraZeneca and Merck.
There is no fee to participate; registration required.
- 1.00 AMA PRA Category 1 Credit™
- 1.00 Participation