Evolving Treatment Paradigms for Bladder Cancer: Expert Perspectives on the Latest Data

• Appraise the expanding clinical trial evidentiary base in NMIBC and MIBC, including newly-approved indications, recently-reported data, and current consensus guideline recommendations for treatment.
• Examine the evolving bladder cancer management calculus in non-metastatic disease, with a focus on evidence-based treatment sequencing strategies and/or combinatorial regimens incorporating intravesical chemotherapy, BCG, platinum chemotherapy, immune checkpoint inhibitors, and surgical modalities.
• Design evidence-supported treatment plans for patients with bladder cancer, both in NMIBC and as neoadjuvant/adjuvant therapy in MIBC, by effectively integrating consensus guideline recommendations with patient-centric factors (i.e., performance status, renal function, PD-L1 expression, cytopathology, urinary markers, etc.).
• Identify immune-mediated adverse events (imAEs) that may occur in patients with bladder cancer receiving immune checkpoint inhibitors, either as monotherapy or in combination, and implement adaptive imAE anticipation, recognition, and management strategies.

Supported through an independent educational grant from AstraZeneca.

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Planners/Faculty:
Sam S. Chang, MD, MBA-has disclosed that he is a consultant for Janssen, MIR, Pacific Edge, Merck, Pfizer, Prokarium, Photocuret, Urigen, and UroToday.

Shilpa Gupta, MD-has disclosed that she is a member of the Speakers’ Bureau for BMS, Gilead, SeaGen, and Janssen. She is a consultant for BMS, EMD Serono, Loxo Oncology, Merck, Natera, Pfizer, and SeaGen. She also has equity in Biontek and Moderna.

Peer Reviewer:
Bashir Al Hussein, MD-has no relevant financial relationships to disclose in relation to the content of this activity.

CEC Staff/Planners:
Susan Gitzinger, PharmD, MPA–has no relevant financial relationships to disclose in relation to the content of this activity.
Ashley C. Lilly, MHA–has no relevant financial relationships to disclose in relation to the content of this activity.

Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CEC, the faculty, and any commercial supporter of this activity do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.